Black Seed Medical Studies

Nigella sativa has attracted healers in ancient civilizations and researchers in recent times. Traditionally, it has been used in different forms to treat many diseases including asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness and influenza. Experimentally, it has been demonstrated that N. sativa extracts and the main constituent of their volatile oil, thymoquinone, possess antioxidant, anti-inflammatory and hepatoprotective properties.

In this review we aimed at summarizing the most recent investigations related to a few and most important effects of thymoquinone. It is concluded that thymoquinone has evidently proved its activity as hepatoprotective, anti-inflammatory, antioxidant, cytotoxic and anti-cancer chemical, with specific mechanisms of action, which provide support to consider this compound as an emerging drug. Further research is required to make thymoquinone a pharmaceutical preparation ready for clinical trials.

Keywords: Anti-cancer, Anti-inflammatory, Antioxidant, Nigella sativa, Thymoquinone.

Thymoquinone: an emerging natural drug with a wide range of medical applications. Khader M, Eckl PM. Iran J Basic Med Sci. 2014 Dec;17(12):950-7. Review.PMID: 25859298 Free PMC Article Similar articles

Hypertension Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Fallah Huseini H, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S, Fallah Huseini A. Phytother Res. 2013 Dec;27(12):1849-53. doi: 10.1002/ptr.4944. Epub 2013 Feb 25. PMID: 23436437 Similar articles

Diabetes: Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54. PMID: 21675032 Similar articles

Diabetic Wounds

Antimicrobial activity of Nigella sativa L. seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds. Emeka LB, Emeka PM, Khan TM. Pak J Pharm Sci. 2015 Nov;28(6):1985-90.PMID:26639493Similar articles

Plasma Lipid Concentrations Nigella Sativa (Black Seed) Effects on Plasma Lipid Concentrations in Humans: a Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Sahebkar A, Beccuti G, Simental-Mendía LE, Nobili V, Bo S. Pharmacol Res. 2016 Feb 10. pii: S1043-6618(15)30212-7. doi: 10.1016/j.phrs.2016.02.008. [Epub ahead of print] Review. PMID: 26875640 Similar articles

Obesity

Oxidative Stress Responses to Nigella sativa Oil Concurrent with a Low-Calorie Diet in Obese Women: A Randomized, Double-Blind Controlled Clinical Trial.

Namazi N, Mahdavi R, Alizadeh M, Farajnia S. Phytother Res. 2015 Nov;29(11):1722-8. doi: 10.1002/ptr.5417. Epub 2015 Jul 14.PMID:26179113Similar artic les

Obesity and Cardiometabolic risk factors: Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Food Funct. 2015 Jun;6(6):2041-8. doi: 10.1039/c5fo00316d. PMID: 26029855 Similar articles

Irritable Bowel Syndrome Efficacy of Caraway Oil Poultices in Treating Irritable Bowel Syndrome–A Randomized Controlled Cross-Over Trial. Lauche R, Janzen A, Lüdtke R, Cramer H, Dobos G, Langhorst J. Digestion. 2015;92(1):22-31. doi: 10.1159/000398790. Epub 2015 Jun 5. PMID:26044145 Similar articles Select item 2602985510.